Zohydro 10gm Cream

Clotrimazole is an antifungal medication that functions through a multi-step mechanism of action. First, it penetrates fungal cell membranes. It then inhibits the synthesis of ergosterol, a crucial component of the fungal cell membrane. This disruption compromises the integrity of the membrane, leading to increased permeability and leakage of cellular contents. Ultimately, this inhibits fungal growth and replication. Clotrimazole is particularly effective against a wide range of fungal infections, including Candida species and dermatophytes.

Clotrimazole

Antifungal

Cream

This cream is indicated in Fungal and gram-positive bacterial infections of the skin and nails. Fungal otitis externa. Vulvitis; balanitis; treatment of partner to prevent re-infection

Clotrimazole dosage for the indication of fungal skin infections, with a duration of 2-4 weeks or as advised:

• Adults and Children – Apply a thin layer to the affected area twice daily for 2-4 weeks.
  

  In case of Overdose

  Overdose may lead to gastrointestinal distress. Seek medical help if symptoms persist.

  Missed Dose

  If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

  How To Use

  Applied topically to the affected area, usually once or twice daily. Follow the directions for application.

  When Not to Use

  Clotrimazole should not be used if:

  • Hypersensitivity
  • Viral infections
  • Pregnancy (during first trimester, topical use)
    

    Side Effects

    Local mild burning, irritation. Hypersensitivity reactions, erythema or irritation

    Precautions & Warnings

    Avoid contact with eyes

    Drug Interactions

    The drug interactions with clotrimazole include:

    • CYP3A4 Substrates (e.g., statins) – Can increase the levels of these drugs.
    • Warfarin – Can enhance the effects of warfarin, increasing the risk of bleeding.
      

      Food Interactions

      Clotrimazol has no documented food interactions that affect their efficacy or safety.

      Storage/Disposal

      Clotrimazole should be stored at room temperature, away from light and moisture. It should be kept in its original packaging and out of reach of children. Dispose of any expired or unused Clotrimazole according to local disposal guidelines or use a drug take-back program.