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Fosfomycin
Bacterial Infection
The bactericidal action of fosfomycin is due to its inactivation of the enzyme enolpyruvy transferase, thereby irreversibly blocking the condensation of uridine diphosphate N-acetylglucosamine with p-enolpyruvate, one of the first steps in bacterial cell wall synthesis. It also reduces adherence of bacteria to uroepithelial cells.
Adults : IM 1gm every 8hr. IV 1-2 gm every 8 hr. Infants : IM 250mg every 8hr. IV 100-400 mg/kg/day. OR As directed by your physician.
Headache , rash , diarrhoea , nausea , vomiting , anorexia , pigastric discomfort , dizziness , fatigue , pruritis.
Antacids , metoclopramide & drugs altering GI motility.
It is indicated in : Urinary tract infections (+ catheter) caused by multiple resistant E. coli & Klebsiella organisms with proven resistance to all other antibiotics where no other appropriate agent is available.
Fosfomycin is contraindicated in patients with known hypersensitivity to the drugĀ .
Fosfomycin can lead to diarrhea during treatment. In case you have a severe or persistent diarrhea or if you notice that your stool contains blood or mucus, call your doctor immediately. Do not take any medicines which may stop or slow down bowel movement.
Do not give this medicine to children and adolescents under 12 years of age because it has not been studied in this age group.
If you are pregnant or breast-feeding, or think you may be pregnant or are planning to have a baby, ask doctor for advice before taking this medicine.
Fosfomycin may cause dizziness and can therefore have minor influence on the ability to drive and use machines.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.