Usage And Safety
Dosage
Adults : Major drepressive disorder : Initial & maintenance dose : 60mg once daily. Generalized anxiety disorders : 30mg daily, increased if necessary to 60mg once daily , max 120mg daily. Diabetic peripheral neuropathic pain : 60mg once daily , max 120mg in divided doses. Children : Not recommended. OR As directed by your physician.
Side Effects
GI disorders , excessive sweating CNS disorders e.g. dizziness , fatigue , insomnia , somnolence , blurred vision , dysuria , headache , dry mouth , wt loss , palpitation , tremor , tinnitus , muscle spasms , anorexia, increased libido , anxiety , abnormal dreams.
Drug Interactions
CYP1A2 Inhibitors , CYP2D6 Inhibitors , tricyclic antidepressants [TCAs], such as nortriptyline, amitriptyline, and imipramine), phenothiazine and Type 1C anti-arrhythmic (e.g., propafenone, flecainide), Alcohol.
Indication
It is used in depression, anxiety, neuropathic and muscular pain.
When not to Use
The use of MAOIs intended to treat psychiatric disorders with duloxetine or within 5 days of stopping treatment with duloxetine is contraindicated because of an increased risk of serotonin syndrome.
Warnings
Warning 1
It should be discontinued in patients who develop jaundice or other evidence of clinically significant liver dysfunction and should not be resumed unless another cause can be established.
Warning 2
Orthostatic hypotension and syncope have been reported with therapeutic doses of duloxetine. Syncope and orthostatic hypotension tend to occur within the first week of therapy but can occur at any time during duloxetine treatment, particularly after dose increases.
Warning 3
Severe skin reactions, including erythema multiforme and Stevens-Johnson Syndrome (SJS), can occur with Duloxetine.
