Usage And Safety
Dosage
Adults : Oral – 500mg to 1g every 6 hours . Intramuscular (i.m.) injection : 500mg to 1500mg very 4 to 6 hours .The dose may be increased for the treatment of severe infections. Children 2 to 12 years , Oral Half adult dose: 5 to 10mL suspension every 6 hours , Injectable Half adult dose: 250mg every 8 hours . Neonates to 2 years , Neonatal oral drops 0.6ml (90mg) of reconstituted suspension every 4 hours. Administer 0/5 to 1 hour prior to feeding. Always consult your doctor or pharmacist for dose adjustment.
Side Effects
Hemolytic anemia, leucopenia, thrombocytopenia, agranulocytosis , Anaphylaxis , Myoclonus and convulsions , Diarrhoea and nausea , Vomiting , Pseudomembranous colitis , Hepatitis and cholestatic jaundice , Skin rash, urticaria, and pruritus , Bullous reactions (including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis), exfoliative dermatitis and purpura .
Drug Interactions
Probenecid , Oral contraceptives , Sulphonamides and acetylsalicylic acid , Bacteriostatic drugs , allopurinol
Indication
It is indicated for the treatment of the following infections including mixed Grampositive (except methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococcus (MRCoNS)) and Gram-negative infections.
When not to Use
It should not be given to patients with a history of hypersensitivity to beta-lactam antibiotics (e.g., penicillins, cephalosporins) or excipients . It is contraindicated for ocular administration.
Warnings
Warning 1
Caution should be observed when administering neonatal oral drops to babies whose mothers are hypersensitive to penicillin.
Warning 2
Before initiating therapy with this, careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactams.
Warning 3
If an allergic reaction occurs, it should be discontinued and the appropriate alternative therapy instituted. All adverse reactions should be treated symptomatically.
