Dosage
The dosage should be adjusted according to the severity of the disorder and the complaints of the patient. The maximum single dose is 400mg, the maximum daily dose is 1200mg dexibuprofen. Osteoarthritis : The recommended dose is 600mg to 900mg dexibuprofen daily, divided in up to three single doses. The dose may be increased up to 1200mg dexibuprofen per day in patients with acute conditions or exacerbations. Dysmenorrhea : The recommended dose is 600mg to 900mg dexibuprofen daily, divided in up to three single doses. Children : Not recommended. Always consult with your doctor or pharmacist for dose adjustments.
Side Effects
Common : Dyspepsia, diarrhea, nausea, vomiting, abdominal pain, rash, fatigue or drowsiness, headache, dizziness, vertigo, edema and hypertension.Uncommon : Gastrointestinal ulcers and bleeding, ulcerative stomatitis, gastritis, malaena, urticaria, pruritus, purpura (including allergic purpura), angioedema, rhinitis, bronchospasm, insomnia, anxiety, restlessness, visual disturbances and tinnitus.Rare : Gastrointestinal perforation, flatulence, constipation, esophagitis, esophageal strictures, exacerbation of diverticular disease, unspecific hemorrhagic colitis, ulcerative colitis, Crohn’s disease, anaphylactic reactions, psychotic reactions, depression, irritability, disorientation, confusion, agitation, reversible toxic amblyopia, impaired hearing, abnormal liver function, hepatitis, jaundice, blood disorders including thrombocytopenia, leucopenia, granulocytopenia, pancytopenia, agranulocytosis, aplastic anemia or hemolytic anemia.
Drug Interactions
Anti-coagulants, such as warfarin , Methotrexate , Lithium , NSAIDs and salicylates , Diuretics , sulphonylurea , Zidovudine (Azidothymidine) , Pemetrexed , Alcohol , Cyclosporine, tacrolimus, sirolimus and aminoglycoside antibiotic , Corticosteroids , Digoxin , Phenytoin, phenobarbital and rifampicin , Thrombolytics, ticlopidine and antiplatelet agents.
When not to Use
Dexibuprofen is contraindicated in patients: – Previously sensitive to dexibuprofen, to any other NSAID, or to any of the excipients of the product. – In whom substances with a similar action (e.g., aspirin or other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic edema. – With a history of gastrointestinal bleeding or perforation, related to previous NSAID therapy. – With active, or a history of recurrent peptic ulcer/hemorrhage (two or more distinct episodes of proven ulceration or bleeding). – With cerebrovascular bleeding or other active bleedings. – With active Crohn’s disease or active ulcerative colitis. – With severe heart failure. – With severe renal dysfunction (GFR < 30 ml/min). – With severely impaired hepatic function. – From the beginning of 6th month of pregnancy
