Requires Prescription (YES/NO)
Yes
Generics
Diclofenac sodium + Misoprostol
How it works
Diclofenac Sodium/Misoprostol is a nonsteroidal anti-inflammatory drug (NSAID). In pharmacologic studies, diclofenac sodium has shown anti-inflammatory, analgesic and antipyretic properties. The mechanism of action of diclofenac sodium, like other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.
Usage And Safety
Dosage
Osteoarthritis: The recommended dosage for maximal GI mucosal protection is 50mg/200mcg tid. For patients who experience intolerance, 75mg/200mcg bid or 50mg/200mcg bid can be used, but are less effective in preventing ulcers. This fixed combination product, is not appropriate for patients who would not receive the appropriate dose of both ingredients. Children : Not recommended . OR As directed by your physician .
Side Effects
Inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine , thrombotic events, myocardial infarction, and stroke , ulcer or gastrointestinal bleeding .
Drug Interactions
ACE-Inhibitors , Aspirin , Digoxin , Warfarin , Methotrexate , Cyclosporine , Lithium , Antacids , Diuretics
Indication
It is indicated for treatment of the signs and symptoms of osteoarthritis or rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications.
When not to Use
It is contraindicated in patients with hypersensitivity to diclofenac or to misoprostol or other prostaglandins.
Warnings
Warning 1
It contains diclofenac sodium and misoprostol. Administration of misoprostol to women who are pregnant can cause abortion, premature birth, or birth defects.
Warning 2
Uterine rupture has been reported when misoprostol was administered in pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy.
Warning 3
Anemia is sometimes seen in patients receiving NSAIDs, including this medicine.
